Table I.
Associations of the pattern of symptoms (LCA) and SARS-CoV-2 IgG antibody positivity
| Symptom class | SARS-CoV-2 IgG antibodies |
|||||
|---|---|---|---|---|---|---|
| Negative/indeterminate (n = 4670) |
Positive (n = 1995) |
Crude OR (95% CI) | P value | Adjusted OR (95% CI) | P value | |
| Frequency (%) | Frequency (%) | |||||
| 1. All symptoms | 127 (38.0) | 207 (62.0) | 17.57 (13.38-23.08) | <.0001 | 15.69 (11.52-21.37) | <.0001 |
| 2. Muscle ache, headache | 1132 (87.1) | 168 (12.9) | 1.60 (1.28-2.01) | <.0001 | 1.71 (1.32-2.21) | <.0001 |
| 3. Headache, diarrhea, stomach pain | 166 (92.2) | 14 (7.8) | 0.91 (0.52-1.61) | .74 | 0.79 (0.40-1.54) | .48 |
| 4. Fever, cough, muscle ache, anosmia, dysgeusia, headache | 546 (42.6) | 737 (57.4) | 14.55 (11.99-17.67) | <.0001 | 12.76 (10.15-16.06) | <.0001 |
| 5. Fever, cough, muscle ache, headache, diarrhea, stomach pain | 207 (68.5) | 95 (31.5) | 4.95 (3.70-6.62) | <.0001 | 4.38 (3.14-6.12) | <.0001 |
| 6. Fever, cough, muscle ache, headache | 449 (51.8) | 418 (48.2) | 10.04 (8.15-12.36) | <.0001 | 8.67 (6.81-11.04) | <.0001 |
| 7. No symptoms | 1779 (91.5) | 165 (8.5) | 1.00 (reference) | — | 1.00 (reference) | — |
| 8. Anosmia, dysgeusia | 260 (59.5) | 177 (40.5) | 7.34 (5.72-9.41) | <.0001 | 6.98 (5.27-9.25) | <.0001 |
Bivariable logistic regression models were constructed with SARS-CoV-2 IgG test results (positive vs negative/indeterminate) as the dependent variable and symptom pattern (ordinal variable with 8 classes derived from LCA) as the independent variable. Crude ORs and 95% CI were estimated. Multivariable models included age, sex, household size, household sick contacts, self-report of a positive SARS-CoV-2 nasal swab test result as covariables, and state of residence. Adjusted ORs and 95% CI were estimated. Bold indicates statistical significance (P < .05).