Table 1.

Burden testing of categories of rare and common predicted loss-of-function (pLOF) variants with MAF threshold categories of MAF < 0.1% and MAF < 1%

Gene	MAF_gnomAD_GENOME_ALL < 1% (n = 50)	Any missense, splicing, pLOF (n = 1876)	OR	95% CI	Z	P-value	P-value (Fisher)
IFNAR1	4	15	10.7884	3.4466–33.7696	4.09	<0.0001	0.0010845
IFNAR2	4	50	10.5855	3.3817–33.1351	4.05	0.0001	0.037353
IKBKG	1	0	113.727	4.5755–2826.7680	2.89	0.0039	0.025961
IRF3	3	78	1.4714	0.4481–4.8315	0.64	0.5244	0.1961
IRF7	1	23	1.6442	0.2176–12.4211	0.48	0.6298	0.34314
STAT1	1	6	6.3605	0.7514–53.8430	1.7	0.0896	0.15565
STAT2	6	65	3.7993	1.5631–9.2346	2.95	0.0032	0.0069853
TBK1	1	2	19.1224	1.7052–214.4468	2.39	0.0167	0.073966
TICAM1	1	60	0.6177	0.0839–4.5483	0.47	0.6362	0.32894
TLR3	1	76	0.4834	0.0659–3.5472	0.72	0.4747	0.27071
TRAF3	1	6	6.3605	0.7514–53.8430	1.7	0.0896	0.15565

OR, odds ratio; CI, confidence interval.