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. 2021 Jun 17;28(7):594–603. doi: 10.1038/s41594-021-00603-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, Simplified schematic of the experimental design for generating Uhrf1-FLAG-tagged TKO_L and DKO₀ cell lines and their analysis by MS and ChIPmentation. b, Volcano plot of interacting proteins acquired by rapid immunoprecipitation MS in both DKO₀ and TKO_L cells using Uhrf1-FLAG as bait. Known Uhrf1 interactors such as Lig1, heterochromatin- and DNA methylation–associated proteins are indicated. Detailed results are listed in Supplementary Table 3. c, Integrative visualization of DMR loci and the chromatin environment. The signal is displayed as noise-subtracted read enrichment for pooled replicates. n = 2 ChIP-seq samples per condition.