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. 2021 Jul 15;96(10):2561–2575. doi: 10.1016/j.mayocp.2021.07.001

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Evidence of tubular injury with mitochondrial insult and apoptosis in coronavirus disease 2019 kidneys. (A) Ultrastructural evaluation of proximal tubular epithelial cells show cytoplasmic vacuolization and swollen mitochondria with distorted cristae (see inset). (B) The mitochondrial injury includes ring- or donut-shaped mitochondria (arrow). (C) Clathrin-coated vesicles, easily mistaken for the virus, are also noted (arrow). Terminal deoxynucleotidyl transferase of dUTP (TUNEL) assay allows detection of TUNEL-positive cells (black arrow) in tubular epithelial cells of coronavirus disease 2019 kidneys (D), sepsis-associated acute kidney injury (E), and non-sepsis–related acute kidney injury (F).