Table 2.
Summary of Salient Autopsy Findings With Emphasis on Renal Pathologya
| Autopsy characteristics | n (%) |
|---|---|
| SARS-CoV-2 polymerase chain reaction (n=17) | |
| Antemortem positivity | 17 (100) |
| Duration from diagnosis to autopsy (median; range in days) | 12 (0-67) |
| SARS-CoV-2 detected/indeterminate at autopsy | 14 (82) |
| Median postmortem interval, hours | 18 |
| Cause of death (n=17) | |
| Complications of COVID-19 | 16 (94) |
| Ischemic heart disease | 1 (6) |
| Pneumonia/diffuse alveolar damage (n=16) | |
| Acute bronchopneumonia | 8 (50) |
| Acute and organizing bronchopneumonia | 4 (25) |
| Organizing pneumonia | 3 (19) |
| Diffuse alveolar damage | 1 (6) |
| Extent of autolysis (n=17) | |
| Mild | 11 (65) |
| Moderate | 6 (35) |
| Severe | 0 (0) |
| Renal pathology (n=17) | |
| Acute tubular injury | 17 (100) |
| Glomerulitis, moderate | 13 (76) |
| Dominant immunophenotype is mixed macrophage and T cell | 13 (100) |
| Peritubular capillaritis, moderate | 13 (76) |
| Dominant immunophenotype is mixed macrophage and T cell | 13 (100) |
| Tubulointerstital inflammation | |
| Mild | 17 (100) |
| Moderate | 0 (0) |
| Severe | 0 (0) |
| Immunophenotype | |
| Neutrophil | 0 (0) |
| B cell | 3 (18) |
| Mixed macrophage and T cell | 17 (100) |
| Peritubular capillary congestion | 17 (100) |
| Nonimmune glomerular pathology | |
| Nodular diabetic glomerulosclerosis | 1 (6) |
| Acute thrombotic microangiopathy | 0 (0) |
| Vascular pathology (n=17) | |
| Arteriolar hyalinosis, moderate to severe | 11 (65) |
| Arterial sclerosis, moderate to severe | 14 (82) |
| Interstitial fibrosis and tubular atrophy (n=17) | |
| Mild | 17 (100) |
| Moderate | 0 (0) |
| Severe | 0 (0) |
a
COVID-19, coronavirus disease 2019; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.