Table 3.

Demographic and Relevant Clinicopathology Characteristics of Three Acute Kidney Injury Cohorts^a

AKI cohort	Age, years/sex	Comorbidities	COVID-19/days from diagnosis/Rx	Serum creatinine (mg/dL)	AKI stage	Cause of AKI	ATN	Inflammation	TUNEL- positive (cells/hpf)	Capillary congestion	Chronicity	Other organ pathology
COVID-19
1	71/M	HT, CAD	Positive/11/Dexamethasone	7.19	3	COVID-19	+++	PTC-2 G-0 Interstitial	3	+++	Mild IFTA and GS	DAD, acute and organizing pneumonia
2	86/M	HT, CAD, CHF, dementia	Positive/6/none	6.28	3	COVID-19	+++	PTC-2 G-2 Interstitial	4	+++	Mild IFTA and GS	DAD, acute pneumonia
3	80/M	CVA, dementia, cancer	Positive/7/none	1.53	1	COVID-19	+++	PTC-2 G-2 Interstitial	3	+++	Mild IFTA and GS	DAD, acute pneumonia
4	73/M	DM, Cancer	Positive/ 25/ remdesvir + convalescent plasma	1.04	0	COVID-19	+++	PTC-0 G-0 Interstitial-0	2	+++	Mild IFTA and GS	DAD, organizing diffuse
5	93/M	Dementia, CHF, cancer	Positive/4/None	2.19	2	COVID-19	+++	PTC-2 G-2 Interstitial	3	+++	Mild IFTA and Mild GS	DAD, acute pneumonia
6	77/M	Dementia	Positive/12/None	0.79	1	COVID-19	+++	PTC-2 G-0 Interstitial	3	+++	Mild IFTA and GS	DAD, acute pneumonia
7	69/F	DM, CAD, HT, dementia	Positive/18/None	2.02	2	COVID-19	+++	PTC-0 G-0 Interstitial	4	+++	Mild IFTA and GS	DAD, acute pneumonia
Sepsis
1	49/F	Obesity	Negative	1.41	1	E.coli sepsis with BP	+++	PTC--2 G-2 Interstitial	5	+	Mild IFTA and GS	Organizing and focal acute pneumonia
2	62/M	COPD; HT	Negative	1.6	1	E.coli sepsis with BP	+++	PTC-2 G-1 Interstitial	4	+	Mild IFTA and GS	Acute bronchopneumonia with DAD
3	62/M	Metastatic cancer; HT	Negative	1.76	1	Acute BP	+++	PTC-2 G-2 Interstitial	4	+	Mild IFTA and GS	Acute BP
4	85/F	HT/Carcinoma breast	Negative	1.2	1	Acute BP	+++	PTC-2 G-1 Interstitial	3	+	Mild IFTA and GS	Acute and organizing pneumonia with DAD
5	87/F	DM/HT/ Carcinoma lung	Negative	1.4	1	Acute BP	+++	PTC-2 G-1 Interstitial	3	+	Mild IFTA and GS	Squamous cell carcinoma lung
6	75/F	HT/ Heart failure	Negative	2.33	2	Acute BP	+++	PTC-2 G-1 Interstitial	6	+	Mild IFTA and GS	Gangrene bilateral toes and acute BP
7	78/M	HT/ Valvular heart disease	Negative	1.35	1	Acute BP	+++	PTC-1 G-1 Interstitial	4	+	Mild IFTA and GS	Acute and organizing pneumonia; Pulmonary microthrombi; splenic infarct
Non-sepsis
1	84/M	HT, CAD, dementia	Negative	2.55	I	Hemodynamic	+++	PTC-0 G-1 Interstitial-0	1	_	Mild IFTA and GS	Atherosclerotic cardiovascular disease
2	81/F	CAD, CHF, HT	Negative	0.55	0	Hemodynamic	+++	PTC-0 G-1 Interstitial-0	0	_	Mild IFTA and GS	Ischemic heart disease
3	76/M	Dementia	Negative	1.7	I	Hemodynamic	+++	PTC-0 G-0 Interstitial-0	1	_	Mild IFTA and GS	Atherosclerotic cardiovascular disease
4	64/M	HT, DM, obesity	Negative	0.85	0	Hemodynamic	+++	PTC-0 G-0 Interstitial-0	0	_	Mild IFTA and GS	Atherosclerotic cardiovascular disease
5	66/M	CAD	Negative	1.9	I	Hemodynamic	+++	PTC-0 G-0 Interstitial-0	2	-	Mild IFTA and GS	Ischemic heart disease
6	78/M	HT	Negative	0.78	0	Hemodynamic	+++	PTC-0 G-0 Interstitial-0	1	-	Mild IFTA and GS	Atherosclerotic cardiovascular disease
7	70/M	CAD, HT, DM	Negative	0.9	0	Hemodynamic	+++	PTC-0 G-0 Interstitial-0	0	-	Mild IFTA and GS	Acute myocardial infarction

^aAKI, acute kidney injury; ATN, acute tubular necrosis; BP, bronchopneumonia; CAD, coronary artery disease; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; COVID-19, coronavirus disease 2019; CVA, cerebrovascular accident; DAD, diffuse alveolar damage; DM, diabetes; F, female; G, glomerulitis; GS, glomerulosclerosis; hpf, high power field; HT, hypertension; IFTA, interstitial fibrosis and tubular atrophy; M, male; PTC, peritubular capillary; Rx, treatment; TUNEL, terminal deoxynucleotidyl transferase of dUTP nick end labeling.