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. 2021 May 30;38(7):3531–3549. doi: 10.1007/s12325-021-01770-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — LS mean changes from baseline in biomarkers of mineral and bone homeostasis according to iron treatment. Red arrows indicate infusion of ferric carboxymaltose, 750 mg; blue arrows indicate infusion of iron isomaltoside, 1000 mg. *P < 0.05, **P < 0.01, ***P < 0.001 between-group comparisons from a mixed model for repeated measures analysis with treatment day, treatment-by-day, trial and stratum as fixed effects and baseline value and baseline value-by-day as covariates; safety analysis set. FCM, ferric carboxymaltose; FGF23, fibroblast growth factor 23; IIM, iron isomaltoside 1000/ferric derisomaltose; LS, least squares; SE, standard error. Reproduced with permission from JAMA. 2020;323(5):432–443. Copyright©(2020) American Medical Association. All rights reserved.