Table 1.

Main characteristics of the articles selected and revised

Authors, country, year	Cancer type	Treatments compared	Patients treated with Durv + Trem	References
Lung and mesothelioma
Antonia et al.; USA, 2016	NSCLC	Durv + Trem	102	[14]
Rizvi et al.; multinational, 2020	NSCLC	Durv vs Durv + Trem vs C	371	[15]
Planchard et al.; multinational, 2020	NSCLC	Durv vs Durv + Trem vs Trem vs SoC	174	[16]
Juergens et al.; Canada, 2020	NSCLC	Durv + Trem + several C	73	[17]
Goldman et al.; multinational, 2020	SCLC	Durv + Trem + Plat-Eto vs Durv + Plat-Eto vs Plat-Eto	268	[18]
Pakkala et al.; USA, 2020	SCLC	Durv + Trem + Radio vs Durv + Trem	18	[19]
Juergens et al.; Canada, 2020	SCLC	Durv + Trem + several C	18	[17]
Calabrò et al.; Italy, 2018	Mesothelioma	Durv + Trem	40	[20]
Juergens et al.; Canada, 2020	Mesothelioma	Durv + Trem + several C	7	[17]
Kim et al.; Korea, 2020	Pulmonary sarcomatoid carcinoma	Durv + Trem	18	[21]
Head and neck cancer
Siu et al.; multinational, 2018	HNSCC	Durv vs Trem vs Durv + Trem	133	[22]
Ferris et al.; multinational, 2020	HNSCC	Durv vs Durv + Trem vs SoC	247	[23]
Juergens et al.; Canada, 2020	HNSCC	Durv + Trem + several C	1	[17]
Gastrointestinal cancer
Segal et al.; USA, 2021	Colorectal cancer	Durv + Trem + Radio	24	[24]
Kelly et al.; multinational, 2020	Gastric and gastroesophageal cancer	Durv vs Trem vs Durv + Trem	52	[25]
O’Reilly et al.; USA, 2019	Pancreatic cancer	Durv vs Durv + Trem	32	[26]
Xie et al.; USA, 2020	Pancreatic cancer	Durv + Radio vs Durv + Trem + Radio	35	[27]
Juergens et al.; Canada, 2020	Pancreatic cancer	Durv + Trem + several C	4	[17]
Boilève et al.; France, 2021	Biliary tract cancer	Durv + Trem vs Durv + Trem + paclitaxel	20	[28]
Urogenital cancer
Gao et al.; USA, 2020	Urothelial cancer	Durv + Trem	45	[29]
Powels et al.; multinational, 2020	Urothelial cancer	Durv vs Durv + Trem + SoC	340	[30]
Sarfaty et al.; USA, 2021	Non-urothelial urinary cancer	Durv + Trem	13	[31]
Juergens et al.; Canada, 2020	Bladder cancer	Durv + Trem + several C	9	[17]
Necchi et al.; Italy, 2018	Germ cell tumors	Durv vs Durv + Trem	11	[32]

C chemotherapy, Durv durvalumab, HNSCC head and neck squamous cell cancer, NSCLC non-small cell lung cancer, Plat-Eto platinum-etoposide, Radio radiation therapy, SCLC small cell lung cancer, SoC standard of care, Trem tremelimumab