Table 2.

Effect of cariprazine versus risperidone in patients with schizophrenia and predominant negative symptoms after 26 weeks of treatment

Outcomes	Cariprazine (n = 227) versus risperidone (n = 229)
	LSMD (95% CI)	P value
PANSS-FSNS	− 1.46 (− 2.4, − 0.5)	0.0022
PSP total score	− 4.63 (2.7, 6.6)	< 0.0001
PSP subdomains
Self-care improvement	− 0.20 (− 0.3, − 0.1)	0.0044
Socially useful activities	− 0.35 (− 0.5, − 0.2)	< 0.0001
Personal and social relationship	− 0.24 (− 0.4, − 0.1)	0.0009
Disturbing and aggressive behavior	− 0.02 (− 0.1, 0.0)	0.30

LSMD least squares mean difference, PANSS-FSNS PANSS-Factor Score for Negative Symptoms, PSP Personal and Social Performance