| There is a high risk of subclinical spread in certain subsets of MIS (lentigo maligna, head and neck location, diameter ≥ 3 cm), requiring a wider clinical margin (10–15 mm) than for other forms of MIS to achieve histologic clearance |
| A “one size fits all” approach to surgical margins for MIS is not appropriate |
| Clinical judgement is needed to tailor surgical margins in the management of MIS |
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