Table 1.

Summary of confirmed expression and functional significance of the most relevant FGFs and FGFRs in the nervous system (+ indicates presence or positive effect, - indicates absence or negative effect; see text for references)

FGF	−1	−2	−7	−8	−9	−20	−22	R1	R2	R3
Absolutely required for CNS development				+				+	+
Abundance in the adult nervous system	+	+						+	+	+
Lack of signal peptide	+	+			+	+
Nuclear localisation	+	+						+
Expressed in neurons	+	+	+	+	+	+	+	+	+	+
Expressed in astrocytes	+	+			+			+	+	+
Expressed in oligodendrocytes	+	+			+			+	+	+
Expressed in microglia	+	+						+		+
Schwann cell proliferation		+						+	+
Astrocyte proliferation	+	+						+	+
Glioma proliferation	+	+						+	(−)	+
Enhanced ECM production		+
Neurogenesis		+		+		+		+	+
Excitatory synapse formation							+	+	+
Inhibitory synapse formation			+						+
Stimulation of LTP	+	+						+
Neuronal survival	+	+	+	+		+		+		–
Up-regulation after peripheral nerve lesion	+	+	+							+
Promotion of axonal regeneration in the PNS	+	+						+
Axonal elongation (in pre-lesioned neurons)	+	+						+
Axonal branching (in naive neurons)	+	+						+
Interaction with myelin inhibitory signalling	+	+						+
Noci- and thermoception		+	+					+	+
Seizure induction	–	+	–				+