Recommendation 3: Surgical options for breast cancer patients with BRCA1/2 mutation.

	Surgical options for breast cancer patients with BRCA1/2 mutation	Level of evidence	Recommendation strength
3.1	Breast-conserving surgery with adjuvant radiotherapy (RT) to the whole breast[6,9–12]	I	A
3.2	Mastectomy[6,8,11,12]	I	A
3.3	Mastectomy∗ combined with immediate breast reconstruction[6,8,11,12]	I	A
3.4	Contralateral prophylactic mastectomy∗ with or without immediate breast reconstruction[6]	II	B

^∗Including nipple-areolar complex (NAC)-sparing or skin-sparing mastectomy.