Table 3.

Univariable and multivariable Cox regression analyses of BCRFS.

	Univariable		Multivariable
	HR (95% CI)	P	HR (95% CI)	P
Age	0.981 (0.954–1.008)	0.168	–	–
BMI	1.023 (0.963–1.087)	0.459	–	–
Pre-operative PSA (ng/mL)
<10	1.000 (reference)		1.000 (reference)
10–20	1.090 (0.654–1.817)	0.740	1.071 (0.638–1.795)	0.921
>20	2.773 (1.759–4.374)	<0.001	1.669 (0.995–2.799)	0.075
PSA nadir (ng/mL)
<0.01	1.000 (reference)		1.000 (reference)
≥0.01	3.959 (2.663–5.887)	<0.001	4.531 (2.993–6.861)	<0.001
Gleason score
≤3 + 4	1.000 (reference)		1.000 (reference)
≥4 + 3	2.310 (1.496–3.568)	<0.001	2.090 (1.277–3.420)	0.003
SM
Negative	1.000 (reference)		1.000 (reference)
Positive	1.966 (1.326–2.916)	<0.001	1.675 (1.076–2.610)	0.007
ECE
No	1.000 (reference)		1.000 (reference)
Yes	1.720 (1.155–2.560)	0.008	0.791 (0.469–1.336)	0.376
SVI
No	1.000 (reference)		1.000 (reference)
Yes	2.704 (1.649–4.436)	<0.001	1.723 (0.897–3.307)	0.022
MTD (cm)
≤2.9	1.000 (reference)		1.000 (reference)
>2.9	2.196 (1.425–3.385)	<0.001	1.587 (1.006–2.503)	0.034

BCRFS: BCR-free survival; BMI: Body mass index; CI: Confidence interval; ECE: Extracapsular extension; HR: Hazard ratio; MTD: Maximum tumor diameter; PSA: Prostate-specific antigen; SM: Surgical margin; SVI: Seminal vesicle invasion.