TABLE 2.
Multivariable Analysis of the Association of Interleukin-1 Receptor Antagonist With Decline in Functional Outcome
| Models | Worsening of Pediatric Overall Performance Category | |
|---|---|---|
| OR (95% CI) | p | |
| Model 1 | ||
| Day 1 | ||
| IL-1ra | 1.02 (0.68–1.53) | 0.92 |
| Age | 1.07 (0.98–1.16) | 0.13 |
| Highest OI | 1.02 (0.98–1.05) | 0.40 |
| Day 2 | ||
| IL-1ra | 1.43 (1.03–1.97) | 0.03 |
| Age | 1.09 (1.03–1.17) | < 0.01 |
| Highest OI | 1.02 (0.99–1.04) | 0.24 |
| Day 3 | ||
| IL-1ra | 1.55 (1.06–2.26) | 0.02 |
| Age | 1.09 (1.02–1.17) | 0.01 |
| Highest OI | 1.04 (1.01–1.07) | 0.01 |
| Model 2 | ||
| Day 1 | ||
| IL-1ra | 0.94 (0.63–1.41) | 0.78 |
| Age | 1.03 (0.95–1.13) | 0.46 |
| CV failure | 5.76 (1.17–28.3) | 0.03 |
| Day 2 | ||
| IL-1ra | 1.31 (0.94–1.83) | 0.12 |
| Age | 1.07 (1.00–1.14) | 0.045 |
| CV failure | 6.66 (1.47–30.16) | 0.01 |
| Day 3 | ||
| IL-1ra | 1.45 (0.98–2.13) | 0.06 |
| Age | 1.07 (0.99–1.15) | 0.055 |
| CV failure | 10.87 (1.40–84.67) | 0.02 |
CV = cardiovascular, IL-1ra = interleukin-1 receptor antagonist, OI = oxygenation index, OR = odds ratio.