TABLE 3.
Multivariable Analysis of the Association of Thrombomodulin With Decline in Functional Outcome
| Models | Worsening of Pediatric Overall Performance Category | |
|---|---|---|
| OR (95% CI) | p | |
| Model 1 | ||
| Day 1 | ||
| Thrombomodulin | 1.58 (0.66–3.80) | 0.31 |
| Age | 1.09 (0.99–1.18) | 0.06 |
| Highest OI | 1.01 (0.98–1.05) | 0.47 |
| Day 2 | ||
| Thrombomodulin | 2.19 (1.11–4.30) | 0.02 |
| Age | 1.10 (1.03–1.17) | < 0.01 |
| Highest OI | 1.02 (0.99–1.05) | 0.15 |
| Day 3 | ||
| Thrombomodulin | 3.03 (1.53–6.01) | < 0.01 |
| Age | 1.09 (1.02–1.17) | 0.01 |
| Highest OI | 1.05 (1.02–1.08) | < 0.01 |
| Model 2 | ||
| Day 1 | ||
| Thrombomodulin | 1.52 (0.61–3.79) | 0.37 |
| Age | 1.06 (0.96–1.15) | 0.24 |
| CV failure | 4.36 (0.89–21.35) | 0.07 |
| Day 2 | ||
| Thrombomodulin | 1.97 (0.99–3.92) | 0.052 |
| Age | 1.07 (1.00–1.15) | 0.04 |
| CV failure | 7.56 (1.71–33.52) | < 0.01 |
| Day 3 | ||
| Thrombomodulin | 2.57 (1.24–5.35) | 0.01 |
| Age | 1.07 (0.99–1.15) | 0.054 |
| CV failure | 11.70 (1.51–90.76) | 0.02 |
CV = cardiovascular, OI = oxygenation index, OR = odds ratio.