TABLE 2.

Bedside Assessment of Safety for VT Titration

Physiologic Variables	Mechanism	Threshold (cm H2O)
Plateau pressure	Maximal pressure across the respiratory system at the end of tidal breath	28
	Static total mechanical stress and barotrauma
Transpulmonary plateau pressure	Maximal pressure across the lung at the end of tidal breath	22–24
	Mechanical stress and barotrauma to the lung
Driving pressure	Dynamic pressure change during tidal breath applied to the respiratory system	14
	Dynamic mechanical stress and strain
Driving transpulmonary pressure	Dynamic pressure change during tidal breath applied to the lung	8–10
	Dynamic mechanical stress and strain to the lung
Stress index	`Worsening of respiratory system compliance during tidal breath	1
	Overdistension and barotrauma