Kaplan-Meier estimates of (A) OS and (B) PFS in the pembrolizumab group and the chemotherapy group. For each treatment group, the Kaplan-Meier method was used to estimate OS and PFS, with censoring of data for patients alive or lost to follow-up at the time of last contact for OS or without disease progression or death at last disease assessment without documented disease progression prior to initiation of second-line therapy for PFS. Tick marks indicate censoring times. HR, hazard ratio; NR, not reached; OS, overall survival; PFS, progression-free survival.