. 2021 Jun 7;46(9):1693–1701. doi: 10.1038/s41386-021-01038-x

Table 2.

Results of the analyses of the occurrence rate and entry rate of the CAPs for bilateral and unilateral left amygdala seeds.

SEED	Mixed model	Main effect of Mood	β estimates (SE)			P value
		Main effect of Mood	Euthymia (E)	Depression (D)	Hypomania (H)
BILAT.	INT-CAP
	Occurrence rate	F = 4.1, p = 0.021	17.7 (2.4)	17.9 (3.3)	27.3 (3.2)	H > E, p = 0.009 H > D, p = 0.027
	Entry rate	F = 4.7, p = 0.012	19.0 (2.3)	17.1 (3.0)	27.1 (2.9)	H > E, p = 0.011 H > D, p = 0.008
LEFT	DMN-CAP
	Occurrence rate	F = 3.2, p = 0.048	14.3 (2.0)	22.8 (2.9)	14.2 (2.9)	D > E, p = 0.020 D > H, p = 0.043
	Entry rate	F = 4.6, p = 0.014	14.0 (1.7)	22.7 (2.5)	13.8 (2.5)	D > E, p = 0.006 D > H, p = 0.015
SEED	Regression in the patients			β estimates (SE)	t	p
BILAT.	INT-CAP
	Occurrence rate	YMRS	Global mania	0.73 (0.29)	2.54	0.014
		Y1	Irritable mania	2.81 (0.98)	2.87	0.006
		Y2	Elated mania^a	2.33 (1.11)	2.11	0.039
	Entry rate	YMRS	Global mania	0.65 (0.26)	2.56	0.013
		Y1	Irritable mania	2.4 (0.87)	2.78	0.007
		Y2	Elated mania^a	2.05 (0.98)	2.10	0.040
LEFT	DMN-CAP
	Occurrence rate	MADRS	Global depression	0.82 (0.25)	3.29	0.002
		M1	Sadness	3.45 (1.01)	3.41	0.001
		M2	Negative thoughts	2.74 (0.74)	3.69	0.0004
		M3	Detachment	2.57 (0.81)	3.16	0.002
	Entry rate	MADRS	Global depression	0.77 (0.22)	3.56	0.0007
		M1	Sadness	3.30 (0.88)	3.77	0.0003
		M2	Negative thoughts	2.46 (0.65)	3.79	0.0003
		M3	Detachment	2.23 (0.71)	3.31	0.001
		M4^a	Neurovegetative symptoms	2.27 (1.04)	2.18	0.032

Significant effects of mood (top panel) and significant association with the clinical variables in the patients (bottom panel) are reported.

^aThe association does not survive when antidepressant medication dose is controlled for (see Supplementary Information).