Table 2.

Synthesis of various derivatives of 1,2,4-triazoloquinazolinones 5a–j catalyzed by the nano-ordered Melamine@TMG organocatalyst (1).

Entry	Aldehyde 4	Product 5	Time (min)	Yielda (%)	Mp (°C)
					Found	Reported	References
1	PhCHO	5a	10	98	250–252	248–250	74,77,78
2	2-MeOC6H4CHO	5b	20	90	242–244	240–243	76,83
3	3,4-(MeO)2C6H3CHO	5c	25	89	225–227	–	This work
4	4-MeC6H4CHO	5d	20	86	262–264	264–269	74,78
5	4-ClC6H4CHO	5e	8	98	303–305	303–305	74,78
6	3-O2NC6H4CHO	5f.	5	97	267–269	266–269	74,78
7	4-O2NC6H4CHO	5 g	5	98	294–297	290–294	84
8	4-HOC6H4CHO	5 h	20	91	305–308	> 300	74,78
9	3,4-(Cl)2C6H3CHO	5i	5	99	324–326	–	This work
10	4-FC6H4CHO	5j	5	99	257–259	258–260	85

Reaction conditions: dimedone (2, 1 mmol), 3-amino-1,2,4-triazole (3, 1 mmol), aldehyde (4a–j, 1 mmol), Melamine@TMG nanocatalyst (1, 2.5 mol%, 15 mg) in EtOH (2 mL) at 40 °C.

^bIsolated yield.