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. 2021 Jul 14;12:4303. doi: 10.1038/s41467-021-24632-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Here we demonstrate that the host upregulates LDs following pathogen detection in two waves. The first wave is EGFR dependent which is independent of interferon production, and the second wave is induced via interferon production. During dsDNA stimulation, there is no second wave, and this is hypothesised to be due to a negative regulator of LD accumulation produced by cells during this response. Figure created by authors on BioRender.com.