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. 2021 Jan 26;46(9):1635–1642. doi: 10.1038/s41386-020-00942-y

Fig. 1. Global connectivity from the frontal cortex distinguishes anger levels in PTSD.

Fig. 1

Resting-state fMRI global connectivity values were calculated for 133 brain regions in each participant and then entered into generalized linear models to discover regions that could distinguish healthy controls, low-anger PTSD patients, and high-anger PTSD patients. Two regions survived FDR correction: the left aMFG (A) and the right OFC (C). In both cases, the low-anger group had stronger connectivity than either high-anger patients or healthy controls. In a post hoc, exploratory analysis, global connectivity levels from both the left aMFG (B) and the right OFC (D) inversely correlated with trait anger. *P < 0.05, ***P < 0.001, Sidak correction for multiple comparisons.