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. 2021 Jul 14;11:14500. doi: 10.1038/s41598-021-93642-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Macroscopic evaluation of wound healing. (a) Gross images of wounds on days 7, 10, and 14 after each treatment. (b) Comparison of wound sizes. The wound size on day 0 was defined as 100%. The wound size on day 14 in the animal group of ASC spheroids NS for RU is about 4-times smaller than that in the Untreated RU group (12.8 ± 4.7% vs. 49.1 ± 7.89%, p < 0.01).