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. 2021 Jul 14;12:4314. doi: 10.1038/s41467-021-24467-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — (1) In the IPF lung, there is a proximalization of the distal airway. ACE2 + epithelial cells cluster in the small airways though total ACE2 + cell numbers are similar to control. (2) The viral entry score (accounting for all described putative receptors and proteases) is increased in diseased lungs. (3) Diseased epithelial cells have alterations in key SARS-CoV-2 response genes/pathways. (4) In the CLD lung, there is increased expression of cytotoxicity and exhaustion genes in immune cell populations and alterations in viral response pathways (interferon, antigen presentation). Figure created in Biorender.com.