Table 3.

Summary of retinal imaging studies characterizing human subjects with Huntington’s disease.

Finding	HD vs Controls	No Difference	Genetically confirmed (CAG)	Complete eye exam* excluding confounding disease
OCT
pRNFL thinning	Kersten et al., (2015), Gatto et al., (2018), Gulmez Sevim et al., 2019		Kersten et al., (2015), Gatto et al., (2018), Gulmez Sevim et al., 2019	Kersten et al., (2015), Gatto et al., (2018), Gulmez Sevim et al., 2019
mRNFL thinning	Gulmez Sevim et al., 2019, Andrade et al., (2016)		Gulmez Sevim et al., 2019	Gulmez Sevim et al. 2019, Andrade et al., (2016)
RGC-IPL thinning	Gulmez Sevim et al., 2019, Andrade et al., (2016)
Total macular thinning		Kersten et al., (2015), Gatto et al., (2018)	Kersten et al., (2015), Gatto et al., (2018)	Kersten et al., (2015), Gatto et al., (2018)
Choroidal thinning		Andrade et al. (2016)		Andrade et al. (2016)
ERG
Inner retinal dysfunction
Outer retinal Dysfunction	Pearl et al., (2017); Knapp et al., (2018)		Pearl et al., (2017); Knapp et al., (2018)	Pearl et al., (2017); Knapp et al., (2018)

Abbreviations: = Optical Coherence Tomography, ERG = Electroretinography, HD = Huntington’s Disease, pRNFL = peripapillary retinal nerve fiber layer, mRNFL = macular retinal nerve fiber layer, RGC = Retinal Ganglion Cells, IPL = Inner Plexiform Layer, Blank cells indicate no data or study was available for that parameters.

^(*)Complete eye exam includes visual acuity, intraocular pressure measurement, and dilated fundus examination.