Table 4.
Summary of retinal imaging studies characterizing human subjects with frontotemporal dementia.
| Finding | FTD vs Controls | No Difference | Biomarker confirmed (tauopathy, TAR DNA–binding protein 43) |
Complete eye exam* excluding confounding disease |
|---|---|---|---|---|
| OCT | ||||
| pRNFL thinning | Ferrari et al. (2017) | |||
| mRNFL thinning | Kim et al., (2017); Kim et al., 2019a,b | Kim et al., (2017); Kim et al., 2019a,b | ||
| RGC-IPL thinning | Kim et al., (2017); Kim et al., 2019a,b | Kim et al., (2017); Kim et al., 2019a,b | ||
| Total macular thinning | Kim et al., (2017); Kim et al., 2019a,b | Kim et al., (2017); Kim et al., 2019a,b |
Abbreviations: = Optical Coherence Tomography, FTD = Frontotemporal Dementia, pRNFL = peripapillary retinal nerve fiber layer, mRNFL = macular retinal nerve fiber layer, RGC = Retinal Ganglion Cells, IPL = Inner Plexiform Layer, Blank cells indicate no data or study was available for that parameters.
(*)
Complete eye exam includes visual acuity, intraocular pressure measurement, and dilated fundus examination.