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. 2021 Jun 15;14(4):321–338. doi: 10.1007/s12195-021-00678-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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VEGF generation rate is fit using pharmacokinetic model of AZD8601 injections. (a) PK model (solid purple line) and PDE model (dashed green line) predict mRNA amount (μg) following injection of 100 μg AZD8601. (b) Experimental measurements of VEGF-A concentration were taken at 6, 24, 48, 72, and 144 h after injection with 100 μg AZD8601 (blue circles). PK model (solid blue line) and PDE model (solid yellow line) predict temporal dynamics of VEGF-A concentration (pg/mg tissue) following injection of 100 μg AZD8601.