Table 1.

Impact on fertility induced by disease-modifying therapies in multiple sclerosis.

Drug	Effect on fertility
Interferon beta	No effect on fertility.
Glatiramer acetate	No effect on fertility.
Dimethyl fumarate	In animal studies reduction of estrogen, but no effect on fertility.
Fingolimod	No effect on fertility.
Siponimod	No effect on fertility.
Teriflunomide	In male animal studies reduction of sperm count, but no effect on fertility.
Cladribine	In male animal studies reduction of germ cells and sperm count, but no effect on fertility.
Natalizumab	In animal studies reduction in fertility. No data in humans.
Alemtuzumab	In animal studies reduction in corpora lutea and implantation in uterus. No data in humans.
Ocrelizumab	No effect on fertility.