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. 2020 Nov 20;224(2):345–350. doi: 10.1093/infdis/jiaa719

Figure 2.

Figure 2.

B-cell deficiency affects the efficacy of doxycycline against Borrelia burgdorferi in vivo. C57BL/6 wild-type (WT) (n = 13), C57BL/6 severe combined immunodeficiency (SCID) (n = 12), muMt–/– (n = 11), or TCRα –/– (n = 12) mice were infected with B. burgdorferi N40 for 24 days and treated with 0.2% doxycycline in drinking water for 5 days. Ear punches were taken every day during treatment and cultured in Barbour-Stoenner-Kelly (BSK)–II media. Mice were sacrificed 2 days after the end of treatment and ear, joint, and heart were cultured in BSK-II media. Cultures were examined under dark-field microscope for about 2 weeks. Time to culture negativity was significantly different between WT vs SCID (P < .0001) and muMt–/– (P < .0001) but not TCRα –/– (P = .4794). P values were calculated using log-rank test.