Fig. 2.

Coexpression network analysis and functional enrichment network for the identified genes. a PCA plot before batch effect removal based on gene expression and after ComBat batch effect removal. Dots with different colors correspond to different brain regions. b Relationships of MEs (module eigengenes) and ASD in the 4 brain region. Each row in the table corresponds to a module. The numbers in the table report the correlations of the corresponding MEs and traits (P < 0.05, modified Bonferroni test). The table is color-coded by correlation according to the color legend. c Bar plot representation of differential gene expression in different brain regions. d Venn diagrams of differentially expressed genes. e The percentages of all differentially expressed genes distributed in the brain regions are shown in the pie chart. f GO term enrichment analysis of genes in the light yellow SCM of BA8. g GO term enrichment analysis of genes in the dark orange SCM of BA8. h GO term enrichment analysis of genes in the royal blue SCM of BA41-42-22. i GO term enrichment analysis of genes in the salmon SCM of BA41-42-22. The x-axis shows the -log (q-value), and the y-axis shows the GO terms. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)