Fig. 4.

Drug repositioning results and MCKG. a Significant drug-target normalized enrichment score (dtNES) for ASD from BA41-42–22. The x-axis shows the positive dtNES −1 and the negative dtNES + 1, and the y-axis shows the drug name. b Significant CMap connectivity score for ASD from BA41-42–22. The x-axis is the score ((positive score − 95)/10 and (negative score + 95)/10) and the y-axis is the name of the drug. The horizontal bars indicate the computationally predicted therapeutic scores for the drugs based on comparison of the gene expression signatures of the drugs with the NCGs. A negative score indicates that a drug exhibits an expression pattern that is oppositional to the disease; such, drugs are potential therapeutic drugs. c Overview of the knowledge graph and processing pipeline. d Forty-two drug candidates and the mental illness association network from MCKG. Yellow nodes represent drugs, magenta nodes represent mental illnesses, and differently colored edges indicate different relationship types. The pie charts show the percentages of relationship types. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)