Table 1.
Clinically relevant drug to drug interaction concerning colchicine.
| Medication | Drug Class | Type of interaction with colchicine | Alternatives |
|---|---|---|---|
| Verapamil | Calcium Channel Blockers | P-gp & CYP3A4 inhibition | Amlodipine |
| Diltiazem | |||
| Telmisartan | ACE inhibitor | P-gp inhibition | Other RAAS inhibitors |
| Amiodarone | Class III AADs | P-gp inhibition | Sotalol |
| Dronaderone | |||
| Warfarin | Anticoagulant | P-gp inhibition | DOACs |
| Atazanavir | Protease Inhibitors | CYP3A4 inhibition | Colchicine dose adjustment |
| Indinavir | |||
| Nelfinavir | |||
| Saquinavir | |||
| Ritonavir | |||
| Amprenavir | |||
| Fosamprenavir | |||
| Itraconazole | Antifungal | CYP3A4 inhibition | Colchicine dose adjustment |
| Ketoconazole | |||
| Fluconazole | |||
| Clarithromycin | Macrolides | CYP3A4 inhibition | Azithromycin |
| Erythromycin | |||
| Ranolazine | Antianginal | P-gp inhibition | Colchicine dose adjustment |
| Cyclosporine | Immunosuppressant | P-gp inhibition | Colchicine dose adjustment |
| Aprepitant | Antiemetic | CYP3A4 inhibition | Colchicine dose adjustment |
| P-gp: P-glycoprotein | |||