Table 2.
Comparison and single logistic analysis for Characteristics of VAP and Non-VAP patients
| Characteristic | All patients (n = 8163) | Non-VAP Patients (n = 7626) |
VAP Patients (n = 537) |
Statistical magnitude | P | OR (95%CI) | Logit-P |
|---|---|---|---|---|---|---|---|
| Age, Mean ± SD | 64.06 ± 16.28 | 64.19 ± 16.22 | 62.29 ± 16.98 | t = 2.620 | 0.009 | 0.993 (0.988–0.998) | 0.009 |
| Gender, n(%) | χ2 = 0.132 | 0.716 | |||||
| Female | 3223 (39.48) | 3007 (39.43) | 216 (40.22) | Ref | |||
| Male | 4940 (60.52) | 4619 (60.57) | 321 (59.78) | 0.967 (0.809–1.156) | 0.716 | ||
| Ethnicity, n(%) | χ2 = 15.423 | 0.004 | |||||
| White | 5902 (72.30) | 5543 (72.69) | 359 (66.85) | Ref | |||
| Asian | 215 (2.63) | 197 (2.58) | 18 (3.35) | 1.411 (0.861–2.313) | 0.172 | ||
| Black | 563 (6.90) | 515 (6.75) | 48 (8.94) | 1.439 (1.051–1.971) | 0.023 | ||
| Hispanic/latino | 298 (3.65) | 285 (3.74) | 13 (2.42) | 0.704 (0.400–1.240) | 0.225 | ||
| Other | 1185 (14.52) | 1086 (14.24) | 99 (18.44) | 1.408 (1.116–1.775) | 0.004 | ||
| COPD, n(%) | 861 (10.55) | 794 (10.41) | 67 (12.48) | χ2 = 2.267 | 0.132 | 1.227 (0.940–1.601) | 0.133 |
| Heart failure, n(%) | 2107 (25.81) | 1935 (25.37) | 172 (32.03) | χ2 = 11.607 | < 0.001 | 1.386 (1.148–1.674) | < 0.001 |
| Diabetes, n(%) | 2027 (24.83) | 1887 (24.74) | 140 (26.07) | χ2 = 0.473 | 0.492 | 1.073 (0.878–1.309) | 0.492 |
| Septicemia, n(%) | 1493 (18.29) | 1324 (17.36) | 169 (31.47) | χ2 = 66.828 | < 0.001 | 2.186 (1.805–2.647) | < 0.001 |
| SAPSII score, M(Q1,Q3) | 38.00 (30.00,49.00) | 38.00 (30.00,49.00) | 41.00 (31.00,52.00) | Z = 3.679 | < 0.001 | 1.009 (1.003–1.014) | 0.002 |
| SOFA score, Mean ± SD | 7.128 ± 3.581 | 7.096 ± 3.579 | 7.581 ± 3.585 | t = −3.040 | 0.002 | 1.037 (1.013–1.062) | 0.002 |
| Serum Lactate, M(Q1,Q3) | 1.60 (1.10,2.60) | 1.60 (1.10,2.60) | 1.80 (1.20,3.00) | Z = 2.773 | 0.006 | 1.051 (1.011–1.092) | 0.013 |
| WBC, M(Q1,Q3) | 11.60 (8.20,15.70) | 11.50 (8.10,15.70) | 12.00 (8.70,16.20) | Z = 2.068 | 0.039 | 1.010 (1.001–1.018) | 0.022 |
| INR, M(Q1,Q3) | 1.30 (1.10,1.50) | 1.30 (1.10,1.50) | 1.20 (1.10,1.60) | Z = -1.295 | 0.195 | 1.067 (0.998–1.141) | 0.059 |
| Length of ICU stay, M(Q1,Q3) | 3.17 (1.61,6.98) | 2.99 (1.48,6.06) | 12.69 (7.69,20.81) | Z = 27.865 | < 0.001 | 1.140 (1.128–1.152) | < 0.001 |
| Length of hospital stay, M(Q1,Q3) | 8.52 (5.14,14.65) | 8.09 (5.00,13.48) | 18.79 (12.33,26.91) | Z = 21.875 | < 0.001 | 1.046 (1.040–1.052) | < 0.001 |
| Length of ventilation, M(Q1,Q3) | 23.50 (8.63,87.33) | 20.86 (7.85,69.67) | 216.47 (114.57,351.26) | Z = 27.780 | < 0.001 | 1.008 (1.007–1.008) | < 0.001 |
| Antibiotic treatment, n(%) | Z = 18.883 | < 0.001 | |||||
| None | 1266 (15.51) | 1248 (16.37) | 18 (3.35) | Ref | |||
| Single antibiotic | 2623 (32.13) | 2610 (34.23) | 13 (2.42) | 0.346 (0.169–0.707) | 0.004 | ||
| Combined antibiotics | 4274 (52.36) | 3768 (49.41) | 506 (94.23) | 9.311 (5.793–14.963) | < 0.001 | ||
| Pathogens species, n(%) | |||||||
| A.baumannii | 6 (0.07) | 5 (0.07) | 1 (0.19) | – | 0.335 | 2.850 (0.333–24.400) | 0.339 |
| P.aeruginosa | 67 (0.82) | 53 (0.69) | 14 (2.61) | – | < 0.001 | 3.825 (2.108–6.939) | < 0.001 |
| MRSA | 181 (2.22) | 156 (2.05) | 25 (4.66) | χ2 = 15.760 | < 0.001 | 2.339 (1.519–3.602) | < 0.001 |
| K.pneumoniae | 61 (0.75) | 54 (0.71) | 7 (1.30) | – | 0.120 | 1.852 (0.839–4.090) | 0.127 |
| MSSA | 123 (1.51) | 113 (1.48) | 10 (1.86) | χ2 = 0.489 | 0.484 | 1.262 (0.657–2.423) | 0.485 |
| E. coli | 128 (1.57) | 118 (1.55) | 10 (1.86) | χ2 = 0.322 | 0.570 | 1.207 (0.629–2.316) | 0.571 |
| Other pathogens | 770 (9.43) | 690 (9.05) | 80 (14.90) | χ2 = 20.094 | < 0.001 | 1.760 (1.370–2.260) | < 0.001 |
| 90-day mortality, n(%) | 2009 (24.61) | 1830 (24.00) | 179 (33.33) | χ2 = 23.569 | < 0.001 | 1.584 (1.314–1.909) | < 0.001 |
| 180-day mortality, n(%) | 2171 (26.60) | 1969 (25.82) | 202 (37.62) | χ2 = 35.762 | < 0.001 | 1.732 (1.444–2.078) | < 0.001 |
RDW red cell distribution width, COPD chronic obstructive pulmonary disease, SOFA septicemia and heart failure, sequential organ failure assessment, WBC white blood cell, A.baumannii Acinetobacter baumannii, P.aeruginosa Pseudomonas aeruginosa, MRSA methicillin-resistant Staphylococcus aureus K.pneumoniae Klebsiella pneumonia, MSSA methicillin-sensitive Staphylo coccus aureus, E. coli Escherichia coli, SAPSII simplified acute physiology score II