Table 3. Baseline Differences in Serum and Skeletal Muscle Metabolite Concentration Levels between Participants with Low iCRF and High iCRFa,b.
| serum (mM)c | low iCRF (n = 23) | high iCRF (n = 24) | ESf | 95% CI | skeletal muscle (mM·g–1)c | low iCRF (n = 23) | high iCRF (n = 22) | ESf | 95% CI | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2-hydroxy-isocaproate | 0.0608 ± 0.0164 | 0.0701 ± 0.0150 | –0.43 | –1.02 | 0.16 | formateLT | 0.7362 ± 0.4102 | 1.0209 ± 0.5012d | –0.78 | –1.40 | –0.16 |
| asparagine | 0.0362 ± 0.0109 | 0.0435 ± 0.0143 | –0.43 | –1.02 | 0.16 | glutamateLT | 0.7029 ± 0.2472 | 0.8668 ± 0.3464 | –0.29 | –0.89 | 0.31 |
| betaine | 0.0471 ± 0.0121 | 0.0555 ± 0.0133e | –1.02 | –1.64 | –0.40 | NADP+LT | 0.0143 ± 0.0079 | 0.0230 ± 0.0107d | –0.63 | –1.24 | –0.02 |
| choline | 0.0049 ± 0.0026 | 0.0062 ± 0.0020 | –0.54 | –1.14 | 0.05 | O-acetylcarnitineLT | 0.4828 ± 0.3175 | 0.6001 ± 0.2802d | –0.69 | –1.31 | –0.07 |
| dimethylamine | 0.0058 ± 0.0049 | 0.0039 ± 0.0031 | 0.40 | –0.19 | 0.99 | taurineLT | 4.5220 ± 1.8308 | 5.4847 ± 1.9589 | –0.50 | –1.10 | 0.11 |
| glutamine | 0.3228 ± 0.0919 | 0.3871 ± 0.0818d | –0.77 | –1.38 | –0.17 | trimethylamineLT | 0.0290 ± 0.0194 | 0.0373 ± 0.0256 | –0.32 | –0.92 | 0.28 |
| glycine | 0.2179 ± 0.0448 | 0.2427 ± 0.0619 | –0.40 | –0.99 | 0.19 | 3-methylxanthine | 0.1015 ± 0.0484 | 0.0704 ± 0.0320e | 1.16 | 0.51 | 1.80 |
| histidine | 0.0873 ± 0.0112 | 0.0965 ± 0.0183 | –0.47 | –1.06 | 0.12 | acetate | 0.3834 ± 0.2223 | 0.4900 ± 0.1677 | –0.61 | –1.22 | 0.00 |
| ornithine | 0.0250 ± 0.0127 | 0.0343 ± 0.0087e | –1.00 | –1.63 | –0.38 | fumarate | 0.0480 ± 0.0205 | 0.0569 ± 0.0193d | –0.67 | –1.28 | –0.05 |
| proline | 0.1033 ± 0.0536 | 0.1541 ± 0.0688d | –0.84 | –1.45 | –0.23 | lactate | 3.7562 ± 1.5430 | 4.7007 ± 1.7428d | –0.72 | –1.33 | –0.10 |
| succinate | 0.0077 ± 0.0030 | 0.0093 ± 0.0031 | –0.50 | –1.10 | 0.09 | ||||||
| threonine | 0.1141 ± 0.0252 | 0.1327 ± 0.0308d | –0.63 | –1.23 | –0.03 | ||||||
| valine | 0.2659 ± 0.0436 | 0.2961 ± 0.0580 | –0.42 | –1.01 | 0.18 | ||||||
Data are mean ± standard deviation.
iCRF, intrinsic cardiorespiratory fitness; ES, effect size calculated as the standardized difference between participants with low iCRF and high iCRF in standard deviation units; LTdata log-transformed before analysis, including ES when necessary. Participants with low and high iCRF were stratified by the first and third tertiles, respectively, from the distribution of the values of maximal power output.
Group of metabolites with correlation coefficients (r) ≥ |0.2|.
Significant differences when compared to low iCRF (determined by 95% CI of ES that did not cross zero) are represented in bold.
Significant difference in low iCRF (based on P < 0.01 and 95% CI for ES). Body mass was included as a covariate in the analysis of variance.
Effects values adjusted for body mass.