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. 2021 Jul 1;11:656421. doi: 10.3389/fcimb.2021.656421

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Copyright © 2021 Srivastava, Abraham and Mukhopadhyay

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Systematic evolution of ligands by exponential enrichment (SELEX) procedure. A library of aptamers with random oligonucleotides is incubated with target. Unbound aptamers are washed off during multiple round selection. The specific aptamer is enriched from the pool and subjected to various bioanalytical and biological assays. Aptamers are either further developed for several applications like therapeutics and diagnostics (successful) or again feed into the same SELEX cycle (unsuccessful).