Table 2.

Aptamers reported for microbial pathogens and diseases.

S. No.	Target	Diseases or Pathogenic agent	References
DNA aptamer
1.	AS1411	Acute myeloid leukemia	Ireson and Kelland, 2006
2.	SARS-CoV N protein	Pathogenic agent	Cho et al., 2011
3.	E. coli K88	Pathogenic agent	Hong and Sooter, 2015
4.	Salmonella Paratyphi A	Pathogenic agent	Hong and Sooter, 2015
5.	Listeria monocytogenes	Pathogenic agent	Hong and Sooter, 2015
6.	Shigella dysenteriae	Pathogenic agent	Hong and Sooter, 2015
7.	Streptococcus mutans	Pathogenic agent	Hong and Sooter, 2015
8.	Francisella tularensis subspecies(subsp.) japonica bacterial antigen	Pathogenic agent	Hong and Sooter, 2015
9.	HIV reverse transcriptase	Pathogenic agent	Hong and Sooter, 2015
10.	Dengue virus type-2 envelope protein domain III	Pathogenic agent	Hong and Sooter, 2015
11.	HCV envelope surface glycoprotein E2	Pathogenic agent	Hong and Sooter, 2015
12.	Avian influenza H5N1	Pathogenic agent	Hong and Sooter, 2015
13.	Mycobacterium tuberculosis H37Rv	Pathogenic agent	Hong and Sooter, 2015
14.	ARC1772	Thrombosis	Nimjee et al., 2017
15.	PTK7 aptamer	Leukemia	Nimjee et al., 2017
16.	Nu172	Anticoagulation	Maimaitiyiming et al., 2019
17.	E10030	Age-related macular degeneration (AMD)	Maimaitiyiming et al., 2019
18.	N55	Atherosclerosis	Sola et al., 2020
19.	GBI-10	In several types of tumors	Sola et al., 2020
20.	SQ-2	Pancreatic ductal adenocarcinoma (PDAC)	Sola et al., 2020
RNA aptamer
21.	A9 and A10	Prostate cancer	Nimjee et al., 2017
22.	RNA 14-16 against p68, helicase	Liver metastasis	Nimjee et al., 2017
23.	Pegaptanib	AMD	Nimjee et al., 2017
24.	ARC1905	AMD	Maimaitiyiming et al., 2019
25.	ARC19499	Hemophilia	Maimaitiyiming et al., 2019
26.	NOX-H94	Anemia	Maimaitiyiming et al., 2019
27.	EYE001	AMD	Maimaitiyiming et al., 2019
28.	MRP1Apt	Melanoma cancer stem cells	Sola et al., 2020
29.	A1	Breast cancer cells	Sola et al., 2020
30.	G-3	HIV infection blockade	Sola et al., 2020
31.	P30-10-16	Influenza B virus infection blockade	Sola et al., 2020
32.	PB	Prostate cancer	Sola et al., 2020
33.	GL21.T	Axl-dependent cancers	Sola et al., 2020
SOMAmer: Slow-Off-rate-Modified-Aptamer
34.	Clostridium difficile binary toxin (CdtA)	Pathogenic agent	Ochsner et al., 2014
35.	Proprotein convertase subtilisin/kexin type 9	Disease	Gawande et al., 2017
36.	Vaccine antigen in the human papillomavirus (HPV) vaccine Gardasil	Pathogenic agent	Trausch JJ et al., 2017
37.	Glypican-3 SOMAmer	Hepatocellular carcinoma (HCC)	Duo et al., 2018
38.	Mycobacterium tuberculosis	Pathogenic agent	Golichenari et al., 2018