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. 2021 Jul 1;9:684505. doi: 10.3389/fcell.2021.684505

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Copyright © 2021 Ji, Tian, Gao, Zang, Wang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-8 enhances ovarian cancer cell stemness through the Notch3-mediated signaling pathway. (A) Examination of Notch3 expression in spheroids by immunocytochemistry. (B) Notch3 activation in cells derived from spheroids. Notch3 was activated (green) in 3-D culture cells with IL-8 overexpression but was decreased in IL-8-silencing cells compared with control cells. DAPI (blue) was used as a nuclear dye. (C) Analysis of cleaved Notch3 by Western blotting in HEY-A8 cells cultured in 2-D and 3-D. IL, interleukin.