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A schematic diagram showing the possible mechanism of IL-8 in ovarian cancer microenvironment. CAF-derived IL-8 can activate the NFs in multiple signal pathways. IL-8 derived from both cancer cells and CAFs can promote proliferation and stemness of cancer cells through the Notch3-mediated signaling. IL, interleukin; CAFs, cancer-associated fibroblasts; NFs, normal ovarian fibroblasts.
