TABLE 4.
Univariate analysis of baseline characteristics associated with incomplete biochemical response to UDCA, according to Paris II criteria
| Baseline characteristic | Univariate analysis | ||
|---|---|---|---|
| OR | 95%CI | p‐value | |
| Sex—male | 0.87 | 0.32–2.36 | 0.058 |
| Age >45 | 0.80 | 0.35–1.83 | 0.162 |
| Asymptomatic | 0.70 | 0.34–1.46 | 0.037 |
| Presence of cirrhosis at diagnosis—Yes | 4.76 | 1.53–14.85 | 0.622 |
| ANA—positive | 0.69 | 0.34–1.38 | 0.037 |
| ALT ≥2xULN | 1.41 | 0.69–2.87 | 0.407 |
| GGT >1.5xULN | 6.37 | 1.96–20.61 | 0.027 |
| ALP ratio a | 1.59 | 1.23–2.04 | 0.028 |
| Bilirubin ratio a | 1.04 | 0.78–1.40 | 0.155 |
Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; ANA, antinuclear antibodies; GGT, gamma‐glutamyl transferase; OR, odds ratio; UDCA, ursodeoxycholic acid; ULN, upper limit of normal; 95%CI, 95% confidence interval.
a
ALP and bilirrubin were analysed as multiples of the upper reference level in the laboratories that measured them.