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. 2021 Jun 21;40(14):e106434. doi: 10.15252/embj.2020106434

Figure 7. A model for negative feedback regulation for homeostasis of SAM synthetase genes in C. elegans .

Figure 7

  • A
    A model for AS‐NMD regulation of the sams genes in C. elegans. See text for details.
  • B
    Modeled structure of C. elegans UAF‐2 binding to 5′‐UAGGU‐3′. The structure was modeled based on sequence homology to U2AF23 from S. pombe (Appendix␣Fig S9) and crystal structure of S. pombe U2AF23/U2AF59 complex bound to the RNA (Yoshida et␣al, 2020). N‐terminal Zn finger 1 (ZnF1), U2AF homology motif (UHM), and C‐terminal Zn finger 2 (ZnF2) domains are colored in blue, yellow and green, respectively. Red spheres indicate zinc ions. The position of the amino group methylated upon m6A modification (N 6) is indicated with an arrowhead.