Table 4.
In vitro kinetic release of Ru and Pip at pH 7.4 from the nanoformulations.
| Kinetic model and release parameters | Nanoformulation |
|||||||
|---|---|---|---|---|---|---|---|---|
| F1, ZrMOFTS-Ru | F2, ZrMOFTS-Pip | F3, ZrMOFTS-Ru-Pip (examining Ru release) | F3, ZrMOFTS-Ru-Pip (examining Pip release) | F4, TiMOFTS-Ru | F5, TiMOFTS-Pip | F6, TiMOFTS-Ru-Pip (examining Ru release) | F6, TiMOFTS-Ru-Pip (examining Pip release) | |
| Kinetic model | Korsmeyer–Peppas (power law) | |||||||
| R 2 | 0.99 ± 0.02 | |||||||
| MCRP | 91.43 ± 3.59 | 90.81 ± 5.07 | 62.08 ± 2.04 | 56.08 ± 1.10 | 92.64 ± 4.25 | 92.06 ± 3.82 | 70.53 ± 2.12 | 64.86 ± 1.01 |
| MRE (% ±SD) | 57.51 ± 1.00 | 69.52 ± 2.10 | 44.56 ± 1.10 | 43.89 ± 1.53 | 61.43 ± 1.11 | 62.90 ± 2.41 | 48.01 ± 1.00 | 49.51 ± 2.04 |
| MRR (%/h ± SD) | 3.02 ± 0.05 | 4.12 ± 0.02 | 2.26 ± 0.01 | 2.07 ± 0.01 | 3.88 ± 0.02 | 3.14 ± 0.01 | 2.98 ± 0.01 | 2.35 ± 0.02 |
| MRT (h) | 17.81 ± 0.42 | 11.26 ± 0.41 | 13.75 ± 0.30 | 10.01 ± 0.25 | 16.17 ± 0.13 | 15.20 ± 0.25 | 12.33 ± 0.41 | 9.36 ± 0.09 |