Table 1.
Conical pathway expression between Con and 100 ng LPS treatments
| Function | Pathways | Fold change (−log P-value)1 | Z-score2 |
|---|---|---|---|
| Cell biosynthesis and turnover | IGF-1 | 2.9 | 0.707 |
| EGF | 2.6 | 0.816 | |
| ErbB2-ErbB3 | 2.24 | −0.447 | |
| ILK | 2.05 | 1 | |
| cAMP | 1.88 | −0.302 | |
| PI3K | 1.63 | 1.414 | |
| ERK5 | 1.46 | 1.342 | |
| Ceramide | 0.848 | 1.89 | |
| Nucleic modification | Unfolded protein | 5.93 | 0.378 |
| Telomerase | 3.43 | 0.707 | |
| HMGB1 | 2.5 | 1.414 | |
| EIF2 | 1.94 | 0.333 | |
| Neurotrophin/TRK | 1.91 | 0.816 | |
| JAK/Stat | 1.81 | 0.816 | |
| Oxidative response/autophagy | NRF2 oxidative stress resp. | 6.48 | 1.265 |
| IL-6 | 3.49 | −0.905 | |
| p38 MAPK | 3.09 | 1 | |
| Sumoylation | 2.35 | 1.633 | |
| TNFR-2 | 2.19 | 2 | |
| CXCR4 | 2.01 | 0.707 | |
| IL-8 | 1.52 | 0.632 | |
| NO/ROS prod. In Macrophages | 1.31 | 0.333 | |
| IL-3 | 1.31 | 1.342 | |
| Muscle function oxidative stress | eNOS signaling | 2.63 | −2.121 |
| Agrin | 1.84 | 1.342 | |
| Calcium signaling | 1.81 | −1.633 | |
| PPARα/RXRα | 1.65 | −1.265 | |
| D-myo-inositol-tetrakiphosphate | 1.59 | 0.707 |
1Pathway expressions are statistically significant (P < 0.05). 2Numerical values denote degree of z-score (positive = upregulated to 100 ng LPS; negative = upregulated to Con) and gross fold change (−log P-value).