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. 2021 Jul 9;2(7):864–883.e9. doi: 10.1016/j.medj.2021.04.013

Figure 2.

Figure 2

Mice with arthritis display intestinal permeability and intestinal inflammation

(A) Concentration of LBP in serum of K/BxN mice at marked ages and naive C57BL/6 control mice (n = 3/group), as measured by ELISA.

(B) Correlation of serum LBP concentration with increase in joint size in 4- to 5-week-old K/BxN mice (n = 8).

(C) Concentration of FITC-dextran in serum of naive C57BL/6 control mice (CTRL) (n = 9) and K/BxN mice with early arthritis (n = 7) and with established arthritis (n = 9).

(D–J) Representative (D) ZO-1 staining, (E) mean ZO-1 intensity, (F) H&E staining, (G) histological scores, (H) MUC2 staining, (I) mean MUC2 intensity, and (J) goblet cell counts from periodic acid-Schiff (PAS) staining for SI of K/BxN mice throughout arthritis development and compared to naive C57BL/6 control mice.

∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001. (A, C, E, I, and J) One-way ANOVA, (B) Pearson’s correlations, and (G) two-way ANOVA. For all panels, one out of two experiments is shown. Data represent mean ± S.E.M.