Figure 5.

Claudin8⁻/⁻ mice have increased gut permeability and develop more severe arthritis

(A) FITC-dextran concentration in the serum of naive WT and claudin8^−/− (Cl8ko) mice (n = 11).

(B) Mean clinical score of arthritis in WT and claudin8^−/− mice (n = 7/group).

(C) Mean percentage expression of splenic IFNγ and IL-17 by total CD45⁺ cells from WT and claudin8^−/− mice at day 7 of AIA (n = 7/group).

(D and E) Representative ZO-1 staining and mean ZO-1 intensity in the SI and colon of WT and claudin8^−/− mice on day 3 of AIA, compared to their respective naive controls.

∗p < 0.05; ∗∗p < 0.01. (A, C, and E) Unpaired t test and (B) two-way ANOVA. For all panels, one out of two experiments is shown. Data represent mean ± S.E.M.