Figure 4.

Lipid II binding to the putative MurM binding site

(A), (B), and (C) show the three simulations whereby Lipid II was found to bind in the putative MurM binding site. Each panel shows the MurM binding to Lipid II with respect to the membrane (top), and an enlarged image of the MurM binding to Lipid II, with the membrane removed (bottom). MurM binding site residues K35, W38, R215, and Y219 are depicted in yellow; the Lipid II headgroup and prenyl chain are rendered in red and blue, respectively.

See also Figure S1.