FIG. 5.

Time course of internal longitudinal resistance, r_i, in arterially perfused rabbit papillary muscle after induction of acute myocardial ischemia. In linear cable theory, r_i corresponds to the intracellular cytoplasmic resistance and the cell-to-cell coupling resistance. The change of r_i corresponds to the uncoupling of cells by closure of gap junction channels. Of note, cell-to-cell uncoupling in myocardial ischemia starts only after a peracute phase about 10 –15 min. Reproduced with permission from A. G. Kléber et al., Cir. Res. 61, 2 (1987). Copyright 1987 Wolters Kluwer Health, Inc.³⁷