Table 2.
Correlation of the TILs grade and TLS with clinicopathological characteristics in EBVnGC.
| Characteristics | All cases n (%) | TILs grade | P value | TLS | P value | |||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | Absent | Present | ||||
| Total, n | 804 | 661 (82.2) | 131 (16.3) | 12 (1.5) | 241 (28.5) | 563 (66.5) | ||
| Age, y | 0.089 | 0.010 | ||||||
| <60 | 423 (52.6) | 356 (53.9) | 64 (48.9) | 3 (25.0) | 110 (45.6) | 313 (55.6) | ||
| ≥60 | 381 (47.4) | 305 (46.1) | 67 (51.1) | 9 (75.0) | 131 (54.4) | 250 (44.4) | ||
| Mean ± SD | 57.4 ± 12.6 | 57.0 ± 12.7 | 58.5 ± 12.1 | 64.3 ± 14.1 | 59.1 ± 12.9 | 56.7 ± 12.5 | ||
| Gender | 0.100 | 0.411 | ||||||
| Male | 547 (68.0) | 441 (66.7) | 99 (75.6) | 7 (58.3) | 169 (70.1) | 378 (67.1) | ||
| Female | 257 (32.0) | 220 (33.3) | 32 (24.4) | 5 (41.7) | 72 (29.9) | 185 (32.9) | ||
| Location | 0.505 | 0.021 | ||||||
| Cardia, fundus | 210 (26.1) | 173 (26.2) | 32 (24.4) | 5 (41.7) | 60 (24.9) | 150 (26.6) | ||
| Body | 195 (24.3) | 164 (24.8) | 27 (20.6) | 4 (33.3) | 50 (20.7) | 145(25.8) | ||
| Antrum | 371 (46.1) | 300 (45.4) | 68 (51.9) | 3 (25.0) | 116 (48.1) | 255 (45.3) | ||
| Remnant/Multiple sites | 28 (3.5) | 24 (3.6) | 4 (3.1) | 0 | 15 (6.2) | 13 (2.3) | ||
| Size | 0.028 | 0.013 | ||||||
| <5 cm | 441 (54.9) | 366 (55.4) | 73 (55.7) | 2 (16.7) | 116 (48.1) | 325 (57.7) | ||
| ≥5 cm | 363 (45.1) | 295 (44.6) | 58 (44.3) | 10 (83.3) | 125 (51.9) | 238 (42.3) | ||
| pTNM stage* | 0.483 | 0.036 | ||||||
| I+II | 353 (43.9) | 285 (43.1) | 61 (46.6) | 7 (43.9) | 92 (38.2) | 261 (46.4) | ||
| III+IV | 451 (56.1) | 376 (56.9) | 70 (53.4) | 5 (41.7) | 149 (61.8) | 302 (53.6) | ||
| Lymphovascular invasion | 0.858 | 0.217 | ||||||
| Absent | 670 (83.3) | 548 (82.9) | 112 (85.5) | 10 (83.3) | 207 (85.9) | 463 (82.2) | ||
| Present | 134 (16.7) | 113 (17.1) | 19 (14.5) | 2 (16.7) | 34 (14.1) | 100 (17.8) | ||
| Perineural invasion | 0.051 | 0.761 | ||||||
| Absent | 664 (82.6) | 537 (81.2) | 115 (87.8) | 12 (100) | 201 (83.4) | 463 (82.2) | ||
| Present | 140 (17.4) | 124 (18.8) | 16 (12.2) | 0 | 40 (16.6) | 100 (17.8) | ||
| Histologic differentiation | 0.411 | 0.007 | ||||||
| Well/Moderate | 214 (26.6) | 182 (27.5) | 30 (22.9) | 2 (16.7) | 80 (33.2) | 134 (23.8) | ||
| Poor | 590 (73.4) | 479 (72.5) | 101(77.1) | 10 (83.3) | 161 (66.8) | 429 (76.2) | ||
| Lauren classification | <0.001 | 0.009 | ||||||
| Intestinal | 215 (26.7) | 184 (27.8) | 30 (22.9) | 1 (8.3) | 80 (33.2) | 135 (24.0) | ||
| Diffuse | 527 (65.5) | 441 (66.7) | 78 (59.5) | 8 (66.7) | 149 (61.8) | 378 (67.1) | ||
| Mixed | 62 (7.7) | 36 (5.4) | 23 (17.6) | 3 (25.0) | 12 (5.0) | 50 (8.9) | ||
| WHO classification | 0.424 | 0.007 | ||||||
| Pap/tub | 218 (27.1) | 185 (28.0) | 31 (23.7) | 2 (16.7) | 81 (33.6) | 137 (24.3) | ||
| Muc/por | 586 (72.9) | 476 (72.0) | 100 (76.3) | 10 (83.3) | 160 (66.4) | 426 (75.7) | ||
EBVnGC, EBV-negative gastric carcinoma; por, poorly cohesive carcinoma; pap, papillary adenocarcinoma; tub, well and moderately differentiated tubular adenocarcinoma; muc, mucinous adenocarcinoma; TILs, tumor-infiltrating lymphocytes; TLS, tertiary lymphoid structures. *The 7th AJCC TNM staging system.