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The cell signaling pathways of irisin are intricate and haven’t been fully identified yet. This figure shows main cellular biological processes concerning atherosclerosis and CHD, which include AMPK-PI3K-Akt-eNOS, AKT/mTOR, p38 MAPK and ERK pathways to regulate inflammation, angiogenesis and other physiological activities. Irisin could also alleviate the damage of ROS directly. Solid lines represent promotion, and dashed lines represent suppression.
