Table 2.

Experimental approaches in lncRNA profiling.

Experimental approaches	Features
RNA-seq	Identifies on novel lncRNA transcripts
Microarray	Reannotations of existing microarrays
	Arrays specifically designed for lncRNAs
Tiling arrays	Ability to profile transciptome for specific regions(whole) in the genome.
SAGE	Accurate quantification and novel transcript identification
CAGE	Identification of transcription start points
PARE, degradome-seq	Used in RNA degradome analysis
GRO-seq	Measures nascent RNA regulating gene transcription
RIP, CLIP	LncRNA-protein interaction identification
TIF-seq	Identification of isoforms of lncRNA
Selective 2'-hydroxyl acylation by primer extension (SHAPE)	LncRNA structure prediction
PARS	LncRNA structure prediction in vitro
FragSeq	Transcript structure prediction from RNA fragments
nextPARS	Adaptation of PARS to Illumina technology