TABLE 3.
Mean differences in the biochemical markers and hemogram parameters between individual with COVID-19 according to the vital status.
| Variable | Mean difference (95% CI) a | p-value | q-value | ||
|---|---|---|---|---|---|
| Lactate Dehydrogenase (U/L) b | 0.26 (0.13, 0.39) | <0.001 | 0.013 | ||
| Troponin I (pg/ml) b | 1.58 (0.78, 2.37) | <0.001 | 0.013 | ||
| C Reactive protein (mg/L) b | 0.76 (0.31, 1.22) | 0.001 | 0.013 | ||
| Procalcitonin (ng/ml) b | 0.77 (0.18, 1.36) | 0.010 | 0.100 | ||
| Neutrophils (/μl) b | 0.27 (0.10, 0.45) | 0.002 | 0.024 | ||
| D-dimer (mg/L) b | 0.59 (0.10, 1.09) | 0.019 | 0.152 | ||
| Interleukin-6 (pg/ml) b | 1.41 (0.37, 2.44) | 0.008 | 0.088 | ||
| Albumin (gr/dL) b | −0.05 (−0.09, −0.00) | 0.058 | 0.406 | ||
| Platelet count (/μl) b | −0.30 (−0.48, −0.12) | 0.001 | 0.013 | ||
| Aspartate transaminase (U/L) b | 0.12 (−0.07, 0.32) | 0.213 | 0.679 | ||
| Alanine transaminase (U/L) b | −0.13 (−0.42, 0.16) | 0.386 | 0. 679 | ||
| γ-Glutamyl transferase (U/L) b | −0.12 (−0.52, 0.28) | 0.556 | 0. 679 | ||
| Ferritin (ng/ml) b | 0.37 (−0.03, 0.77) | 0.070 | 0.420 | ||
| Leukocyte count (/μL) b | 0.23 (0.05, 0.41) | 0.013 | 0.117 | ||
| Lymphocyte count (/μL) b | −0.38 (−0.58, −0.18) | <0.001 | 0.013 | ||
| Total serum proteins (gr/dL) | −0.19 (−0.44, 0.05) | 0.124 | 0.577 | ||
| PaO2/FiO2 ratio b | −0.27 (−0.37, −0.17) | <0.001 | 0.013 | ||
| Fibrinogen (mg/dl) | 17.56 (−65.48,100.60) | 0.679 | 0.679 | ||
a
Mean difference between survivors and deceased along four laboratory measurements (days 0, 3, 6 and 9 after TCZ administration) using generalized estimating equation;
b
Parameters analyzed in logarithmic units; CI: confidence interval; q-value: p-value adjusted by multiple comparisons with Benjamini-Hochber method. In bold if p-value < 0.05.