TABLE 1.
Relevant pattern recognition receptors, cellular localization, and mycobacterial ligand
| PRRs | Cellular localization | Mycobacterial ligand | Reference(s) |
|---|---|---|---|
| C-type lectins | |||
| Dectin-1 | Plasma membrane | Uncharacterized | 23, 27 |
| Dectin-2 | Plasma membrane | ManLAM | 28 |
| Mincle | Plasma membrane | TDM | 31, 32 |
| MCL | Plasma membrane | TDM | 32, 35, 36 |
| MR | Plasma membrane | ManLAM, higher PIMs, LM | 37 |
| Scavenger receptors | |||
| MARCO | Plasma membrane | TDM | 40, 41 |
| SR-A | Plasma membrane | TDM | 40 |
| CD36 | Plasma membrane | ManLAM | 40 |
| Toll-like receptors | |||
| TLR2 | Plasma membrane | LAM, LM, PIM, 19- and 24-kDa lipoprotein of M. tuberculosis | 52–55 |
| TLR4 | Plasma/endosomal membrane | Multiple HSP, M. tuberculosis 50S ribosomal, Cpn 60, 38-kDa glycoprotein of M. tuberculosis | 62–64, 66, 67 |
| TLR9 | Endosomal membrane | CpG in bacterial DNA | 74 |